EGF decreases the abundance of microRNAs that restrain oncogenic transcription factors.

@article{Avraham2010EGFDT,
  title={EGF decreases the abundance of microRNAs that restrain oncogenic transcription factors.},
  author={Roi Avraham and Aldema Sas-Chen and Ohad Manor and Israel Steinfeld and Reut Shalgi and Gabi Tarcic and Noa Bossel and Amit Zeisel and Ido Amit and Yaara Zwang and Espen Enerly and Hege Giercksky Russnes and Francesca Biagioni and Marcella Mottolese and Sabrina Strano and Giovanni Blandino and Anne-Lise B\orresen-Dale and Yitzhak Pilpel and Zohar Yakhini and Eran Segal and Yosef Yarden},
  journal={Science signaling},
  year={2010},
  volume={3 124},
  pages={ra43}
}
Epidermal growth factor (EGF) stimulates cells by launching gene expression programs that are frequently deregulated in cancer. MicroRNAs, which attenuate gene expression by binding complementary regions in messenger RNAs, are broadly implicated in cancer. Using genome-wide approaches, we showed that EGF stimulation initiates a coordinated transcriptional program of microRNAs and transcription factors. The earliest event involved a decrease in the abundance of a subset of 23 microRNAs. This… CONTINUE READING

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