EGF decreases the abundance of microRNAs that restrain oncogenic transcription factors.

  title={EGF decreases the abundance of microRNAs that restrain oncogenic transcription factors.},
  author={Roi Avraham and Aldema Sas-Chen and Ohad Manor and Israel Steinfeld and Reut Shalgi and Gabi Tarcic and Noa Bossel and Amit Zeisel and Ido Amit and Yaara Zwang and Espen Enerly and Hege Giercksky Russnes and Francesca Biagioni and Marcella Mottolese and Sabrina Strano and Giovanni Blandino and Anne-Lise B\orresen-Dale and Yitzhak Pilpel and Zohar Yakhini and Eran Segal and Yosef Yarden},
  journal={Science signaling},
  volume={3 124},
Epidermal growth factor (EGF) stimulates cells by launching gene expression programs that are frequently deregulated in cancer. MicroRNAs, which attenuate gene expression by binding complementary regions in messenger RNAs, are broadly implicated in cancer. Using genome-wide approaches, we showed that EGF stimulation initiates a coordinated transcriptional program of microRNAs and transcription factors. The earliest event involved a decrease in the abundance of a subset of 23 microRNAs. This… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 58 extracted citations

Regulation of primary response genes.

Molecular cell • 2011
View 3 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 61 references

Coordinated cropping and dicing

V. N. Kim, MicroRNA biogenesis
Nat. Rev. Mol. Cell Biol. 6, 376–385 • 2005
View 9 Excerpts
Highly Influenced

Deduced amino acid sequence of the human c-fos protein

F. van Straaten, R. Muller, +3 authors Complete nucleotide sequence of a human c-onc gene
Proc. Natl. Acad. Sci. U.S.A. 80, 3183–3187 • 1983
View 6 Excerpts
Highly Influenced

Gene regulation by transcription factors and microRNAs.

Science • 2008
View 17 Excerpts
Highly Influenced

From developmental defects to psoriasis and skin tumors

R. Zenz, E. F. Wagner, Jun signalling in the epidermis
Int. J. Biochem. Cell Biol. 38, 1043–1049 • 2006
View 4 Excerpts
Highly Influenced

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria

V.K.Mootha, J.Bunkenborg, +10 authors M.Mann
Cell 115, • 2003
View 2 Excerpts
Highly Influenced

EGF decreases the abundance of microRNAs that restrain oncogenic transcription factors

Z. Yakhini
Sci . Signal . • 2010

Similar Papers

Loading similar papers…