EGF-coated nano-dendriplexes for tumor-targeted nucleic acid delivery in vivo.

Abstract

The clinical success of therapeutic DNA is still hindered due to the lack of effective delivery carriers. Here, we designed a tumor-targeted gene nano delivery system based on EGFR targeting strategy. Epidermal growth factor (EGF) was introduced to nano-complexes of PAMAM dendrimer and DNA via electrostatic interactions to form self-assembled PAMAM/DNA/EGF… (More)
DOI: 10.3109/10717544.2015.1004381

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