EGF and angiotensin II modulate lysophosphatidic acid LPA(1) receptor function and phosphorylation state.

@article{ColnSantana2011EGFAA,
  title={EGF and angiotensin II modulate lysophosphatidic acid LPA(1) receptor function and phosphorylation state.},
  author={Christian C. Col{\'i}n-Santana and S. Er{\'e}ndira Avenda{\~n}o-V{\'a}zquez and R J Alc{\'a}ntara-Hern{\'a}ndez and J Adolfo Garc{\'i}a-S{\'a}inz},
  journal={Biochimica et biophysica acta},
  year={2011},
  volume={1810 12},
  pages={
          1170-7
        }
}
BACKGROUND Lysophosphatidic acid (LPA) is a local mediator that exerts its actions through G protein coupled receptors. Knowledge on the regulation of such receptors is scarce to date. Here we show that bidirectional cross-talk exits between LPA(1) and EGF receptors. METHODS C9 cells expressing LPA(1) receptor fussed to the enhanced green fluorescent protein were used. We studied intracellular calcium concentration, Akt/PKB phosphorylation, LPA(1) and EGF receptor phosphorylation. RESULTS… CONTINUE READING
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