EGF and TGF alpha influence in vitro lung development by the induction of matrix-degrading metalloproteinases.

@article{Ganser1991EGFAT,
  title={EGF and TGF alpha influence in vitro lung development by the induction of matrix-degrading metalloproteinases.},
  author={Gail L Ganser and George P Stricklin and Lynn M Matrisian},
  journal={The International journal of developmental biology},
  year={1991},
  volume={35 4},
  pages={453-61}
}
Remodeling of the extracellular matrix by matrix-degrading metalloproteinases (MMPs) has been implicated in the early morphogenesis of branched organs. Growth factors such as EGF and TGF alpha are known to regulate the expression of MMPs in a variety of systems. We therefore examined the effects of EGF, TGF alpha, and collagenase upon in vitro branching of the embryonic lung. Lung rudiments from 11.5 day post coitum mice underwent extensive growth and repetitive branching during a 3-day period… CONTINUE READING
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