EGF Converts Transit-Amplifying Neurogenic Precursors in the Adult Brain into Multipotent Stem Cells

@article{Doetsch2002EGFCT,
  title={EGF Converts Transit-Amplifying Neurogenic Precursors in the Adult Brain into Multipotent Stem Cells},
  author={F. Doetsch and L. Petreanu and I. Caill{\'e} and J. Garc{\'i}a-Verdugo and A. {\'A}lvarez-Buylla},
  journal={Neuron},
  year={2002},
  volume={36},
  pages={1021-1034}
}
Neural stem cells in the subventricular zone (SVZ) continue to generate new neurons in the adult brain. SVZ cells exposed to EGF in culture grow to form neurospheres that are multipotent and self-renewing. We show here that the majority of these EGF-responsive cells are not derived from relatively quiescent stem cells in vivo, but from the highly mitotic, Dlx2(+), transit-amplifying C cells. When exposed to EGF, C cells downregulate Dlx2, arrest neuronal production, and become highly… Expand

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