EGF‐like domains in extracellular matrix proteins: Localized signals for growth and differentiation?

@article{Engel1989EGFlikeDI,
  title={EGF‐like domains in extracellular matrix proteins: Localized signals for growth and differentiation?},
  author={Jürgen Engel},
  journal={FEBS Letters},
  year={1989},
  volume={251}
}
  • J. Engel
  • Published 1989
  • Biology, Medicine
  • FEBS Letters
Multidomain proteins of the extracellular matrix (ECM) play an important role in development and maintenance of cellular organization and in tissue repair. Several ECM proteins such as laminin, tenascin, and thrombospondin contain domains with homology to epidermal growth factor (EGF) and exhibit growth promoting activity. The mitogenic activity of laminin is restricted to a fragment which consists of about 25 repeating domains with partial homology to EGF and comprises the rod‐like inner… Expand
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