EGF/EGFR axis contributes to the progression of cholangiocarcinoma through the induction of an epithelial-mesenchymal transition.

@article{Clapron2014EGFEGFRAC,
  title={EGF/EGFR axis contributes to the progression of cholangiocarcinoma through the induction of an epithelial-mesenchymal transition.},
  author={Audrey Clap{\'e}ron and Martine Mergey and Thanh Huong Nguyen Ho-Bouldoires and Danijela Matic Vignjevic and Dominique Wendum and Yves Chr{\'e}tien and Fatiha Merabtene and Alexandra Frazao and Val{\'e}rie Paradis and Chantal Housset and Nathalie S. Guedj and Laura Fouassier},
  journal={Journal of hepatology},
  year={2014},
  volume={61 2},
  pages={325-32}
}
BACKGROUND & AIMS Epithelial-mesenchymal transition (EMT) is a cellular process involved in cancer progression. The first step of EMT consists in the disruption of E-cadherin-mediated adherens junctions. Cholangiocarcinoma (CCA), a cancer with a poor prognosis due to local invasion and metastasis, displays EMT features. EGFR, a receptor tyrosine kinase, plays a major role in CCA progression. The aim of the study was to determine if EMT is induced by EGFR in CCA cells. METHODS In vivo, the… CONTINUE READING
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