EGEA (Epidemiological study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy)-- descriptive characteristics.

Abstract

The Epidemiological study on the Genetics and Environment of Asthma (EGEA) was planned to assess genetic, environmental risk factors and their interactions for asthma and for the two related traits of bronchial hyperresponsiveness and atopy. The population examined includes 348 nuclear families ascertained by one asthmatic (213 adult and 135 paediatric probands) and 416 controls, totalling 1,847 subjects (EGEA I). Prevalences of asthma, skin prick test response, high IgE and bronchial hyperresponsiveness were for parents, siblings, and offspring of cases intermediate between cases and spouses or controls, both in adults and children, confirming the familial resemblance for asthma and related traits. With an additional sample of 40 families ascertained by two asthmatic siblings (EGEA II), a total of 119 families with two asthmatic siblings has been ascertained for a genome screening.

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@article{Kauffmann1999EGEAS, title={EGEA (Epidemiological study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy)-- descriptive characteristics.}, author={F Kauffmann and M H Dizier and I Annesi-Maesano and J Bousquet and D Charpin and F Demenais and D Ecochard and J Feingold and F Gormand and A Grimfeld and M Lathrop and R Matran and F Neukirch and E Paty and I Pin and C Pison and P Scheinmann and D Vervloet and A Lockhart}, journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology}, year={1999}, volume={29 Suppl 4}, pages={17-21} }