EGCG protects against homocysteine-induced human umbilical vein endothelial cells apoptosis by modulating mitochondrial-dependent apoptotic signaling and PI3K/Akt/eNOS signaling pathways

@article{Liu2017EGCGPA,
  title={EGCG protects against homocysteine-induced human umbilical vein endothelial cells apoptosis by modulating mitochondrial-dependent apoptotic signaling and PI3K/Akt/eNOS signaling pathways},
  author={Shumin Liu and Z. Sun and P. Chu and Hailong Li and A. Ahsan and Ziru Zhou and Zonghui Zhang and B. Sun and J. Wu and Yalin Xi and G. Han and Yuan Lin and Jinyong Peng and Zeyao Tang},
  journal={Apoptosis},
  year={2017},
  volume={22},
  pages={672-680}
}
Homocysteine (Hcy) induced vascular endothelial injury leads to the progression of endothelial dysfunction in atherosclerosis. Epigallocatechin gallate (EGCG), a natural dietary antioxidant, has been applied to protect against atherosclerosis. However, the underlying protective mechanism of EGCG has not been clarified. The present study investigated the mechanism of EGCG protected against Hcy-induced human umbilical vein endothelial cells (HUVECs) apoptosis. Methyl thiazolyl tetrazolium assay… Expand
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L-Cystathionine Protects against Homocysteine-Induced Mitochondria-Dependent Apoptosis of Vascular Endothelial Cells
  • X. Wang, Yi Wang, +7 authors Hongfang Jin
  • Chemistry, Medicine
  • Oxidative medicine and cellular longevity
  • 2019
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