EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer.

  title={EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer.},
  author={Sharmila Shankar and Suthakar Ganapathy and Sunil Hingorani and Rakesh K Srivastava},
  journal={Frontiers in bioscience : a journal and virtual library},
We have shown that epigallocatechin-3-gallate (EGCG), a polyphenolic compound from green tea, inhibits growth and induces apoptosis in human pancreatic cancer cells. However, the preclinical potential of EGCG in a suitable mouse model has not been examined. In this study, we examined the molecular mechanisms by which EGCG inhibited growth, invasion, metastasis and angiogenesis of human pancreatic cancer cells in a xenograft model system. EGCG inhibited viability, capillary tube formation and… CONTINUE READING

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