EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer.

@article{Shankar2008EGCGIG,
  title={EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer.},
  author={Sharmila Shankar and Suthakar Ganapathy and Sunil Hingorani and Rakesh K Srivastava},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2008},
  volume={13},
  pages={440-52}
}
We have shown that epigallocatechin-3-gallate (EGCG), a polyphenolic compound from green tea, inhibits growth and induces apoptosis in human pancreatic cancer cells. However, the preclinical potential of EGCG in a suitable mouse model has not been examined. In this study, we examined the molecular mechanisms by which EGCG inhibited growth, invasion, metastasis and angiogenesis of human pancreatic cancer cells in a xenograft model system. EGCG inhibited viability, capillary tube formation and… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
99 Extracted Citations
63 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 99 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 63 references

Martin : Matrigel : basement membrane matrix with biological activity

  • H. K. Kleinman, R. G.
  • Semin Cancer Biol
  • 2007

Quigley : Matrix metalloproteinases and tumor metastasis

  • E. I. Deryugina, P. J.
  • Cancer Metastasis Rev
  • 2006

Similar Papers

Loading similar papers…