EFG1 is a major regulator of cell wall dynamics in Candida albicans as revealed by DNA microarrays

  title={EFG1 is a major regulator of cell wall dynamics in Candida albicans as revealed by DNA microarrays},
  author={Kai Sohn and Constantin F. Urban and Herwig Dr Brunner and Steffen Rupp},
  journal={Molecular Microbiology},
Cell wall dynamics in Candida albicans, the most common fungal pathogen in man, underlie regulatory processes during the yeast‐to‐hyphae transition. To analyse this regulation at the transcriptional level, we have established a DNA microarray representing genes implicated in cell wall biogenesis. Using these microarrays, we were able to identify YWP1 and HWP2 that are specifically transcribed in the yeast or hyphal growth form respectively. Cluster analysis revealed at least two major clusters… 

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A Candida albicans regulator of disseminated infection operates primarily as a repressor and governs cell surface remodeling

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Candida albicans Transcription Factor Ace2 Regulates Metabolism and Is Required for Filamentation in Hypoxic Conditions

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Characterizing Genes Of Candida albicans Involved In Invasiveness, Mating And Genotoxic Stress Response

Mms21 deleted mutants, due to increased cellular and genotoxic stress, have increased homozygosis at MTLaa followed by increased white-opaque switching and subsequent mating, providing a direction of how natural Candida MTL a/α cells inside a stressful host environment can achieve mating.

Deletion of the high‐affinity cAMP phosphodiesterase encoded by PDE2 affects stress responses and virulence in Candida albicans

It is suggested thatosphodiesterases, and in particular the high‐affinity cAMP phosphodiesterase encoded by PDE2, have real potential as targets for antifungal chemotherapy.



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A DNA‐binding protein, Nrg1, is identified that represses filamentous growth in Candida probably by acting through the co‐repressor Tup1, and expression of NRG1 from a non‐regulated promoter partially blocks the induction of filamentousgrowth.

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Transcriptional Regulators Cph1p and Efg1p Mediate Activation of the Candida albicans Virulence Gene SAP5 during Infection

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