EFFICIENCY OF RECOMBINANT TNF-BINDING PROTEIN FROM VARIOLA VIRUS IN A MODEL OF COLLAGEN-INDUCED ARTHRITIS

@inproceedings{2014EFFICIENCYOR,
  title={EFFICIENCY OF RECOMBINANT TNF-BINDING PROTEIN FROM VARIOLA VIRUS IN A MODEL OF COLLAGEN-INDUCED ARTHRITIS},
  author={Дондок Дамдинович Цырендоржиев and С. В. Сенников and И. А. Орловская and И. П. Гилева and И. А. Рязанкин and Л. Б. Топоркова and В. В. Курилин and Ю. А. Лопатникова and А. А. Грыдина and С. Н. Щелкунов},
  year={2014}
}
Abstract. This paper presents the results of the research on the effectiveness of recombinant TNF-binding protein of variola virus (VARV-CrmB) in a model of collagen-induced arthritis (CIA) in mice (CBAxC57Bl6) F1. The introduction of VARV-CrmB and polyclonal antibody to recombinant mouse TNF (poly-AbMuTNF) led to an improvement of clinical manifestations of CIA by reducing the swelling and increasing the mobility of mice limbs. The introduction of VARV-CrmB and poly-AbMuTNF reduced the number… Expand
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