EFFECTS OF SOME HYPNOTIC DRUGS ON RESPIRATION AND OXIDATIVE PHOSPHORYLATION IN RAT BRAIN.

@article{Erwin1963EFFECTSOS,
  title={EFFECTS OF SOME HYPNOTIC DRUGS ON RESPIRATION AND OXIDATIVE PHOSPHORYLATION IN RAT BRAIN.},
  author={V. Gene Erwin and Harold C. Heim},
  journal={Journal of pharmaceutical sciences},
  year={1963},
  volume={52},
  pages={
          747-51
        }
}
  • V. Erwin, H. Heim
  • Published 1 August 1963
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
Pentobarbital and glutethimide inhibited respiration of rat brain homogenates in the presence of glucose, pyruvate, malate, or glutamate. These effects were not evoked by ethinamate or methyprylon. None of the drugs produced effects on malic dehydrogenase activity, but both pentobarbital and glutethimide inhibited the oxidation of reduced diphosphopyridine nucleotide. Of the four drugs studied only pentobarbital produced significant effects on oxidative phosphorylation by mitochondria. 
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