EFFECTS OF POTASSIUM ON OUABAIN-INDUCED ARRHYTHMIAS.

@article{Vassalle1963EFFECTSOP,
  title={EFFECTS OF POTASSIUM ON OUABAIN-INDUCED ARRHYTHMIAS.},
  author={Mario Vassalle and Kalman Greenspan},
  journal={The American journal of cardiology},
  year={1963},
  volume={12},
  pages={
          692-701
        }
}
Use of Potassium Canrenoate to Suppress Ouabain‐Induced Ventricular Arrhythmias in Dogs
TLDR
The antiarrhythmic activity of potassium canrenoate does not seem to be related to the potassium ion in the molecule, so the compound may be a valuable clinical agent for patients on digitalis therapy.
Effects of Verapamil on Ventricular Tachycardia Induced by Ouabain in Guinea Pigs
TLDR
Results show that pretreatmenf with verapamil inhibits ouabain‐induced ventricular tachycardia in guinea pigs, which is associated with a high incidence of heart block and asystole, which may limit the usefulness of verAPamil.
Electrophysiological Observations on the Digitalis‐Potassium Interaction in Canine Purkinje Fibers
TLDR
These studies suggest that elevation of [K]o reverses digitalis toxic manifestations in canine Purkinje fibers by causing release of cardiac glycosides bound to the membrane.
The Spread of Sinus Activation During Potassium Administration
TLDR
It was found that sinus activity propagates to the coronary sinus and ventricles at a time when the atrial muscle fibers have been rendered inexcitable, and the finding of such a sino-ventricular rhythm supports the existence of a specialized conducting path between thesinus and the atrio- ventricular node; this path is particularly resistant to depolarization by potassium.
Role of electrolytes in etiology and management of cardiac arrhythmias.
  • B. Surawicz
  • Medicine
    Progress in cardiovascular diseases
  • 1966
...
...

References

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An Analysis of Arrhythmias Induced by Ouabain in Intact Dogs
TLDR
It was demonstrated in this investigation that extra beats appear during slow intravenous administration of ouabain and that they disappear not only on suppression but also on slowing of the sinus rhythm.
ELECTROCARDIOGRAPHIC CHANGES AND CONCENTRATION OF POTASSIUM IN SERUM FOLLOWING INTRAVENOUS INJECTION OF POTASSIUM CHLORIDE
TLDR
The present studies were undertaken to determine what relationship, if any, exists between the concentration of potassium in the serum and the various electrocardiographic changes observed following intravenous injection of an isotonic solution of potassium chloride.
Effect of Potassium on Conduction and Ectopic Rhythms in Atrial Fibrillation Treated with Digitalis
Intravenous administration of potassium to patients with atrial fibrillation treated with digitalis resulted in depression of conduction through the A-V node, appearance of complete A-V dissociation
THE TREATMENT OF CERTAIN CARDIAC ARRHYTHMIAS WITH POTASSIUM SALTS
TLDR
The rationale of potassium therapy of human cardiac arrhythmias is based on experimental evidence, from various sources, that potassium ion excess in the fluid perfusing a heart will prevent extrasystole formation from mechanical, electrical or pharmacologic stimuli.
Digoxin, ouabain and potassium movements in rabbit auricles.
TLDR
Irregularities or failure of contraction occurred when the tissue potassium was reduced by about 15%.
Interrelation between Potassium Metabolism and Digitalis Toxicity in Heart Failure.∗
TLDR
In a series of patients in congestive failure, potassium depletion, either occurring spontaneously with malnutrition and gastrointestinal disorders or induced by mercurial diuresis after pre-treatment with ammonium chloride, was found to be associated with increased sensitivity to digitalis, which is suggested to results from alterations in intracellular potassium distribution.
ouabain contracture of frog heart: Ca 45 movements and effect of EDTA.
TLDR
Observations indicate that the ouabain contracture is not due primarily to an intracellular shift in Na + or K + concentration nor to a gross interference with intrACEllular energy metabolism but could be due to an altered handling of Ca ++ by the oUabain-treated muscle.
Effect of ouabain on potassium exchange in the mammalian heart.
The effect of the digitalis glycoside, ouabain, on potassium exchange in the guinea pig heart in vitro was studied with the aid of K42. With modified Ringer's solution as a perfusate at 38 C, K was...
Potassium and sodium exchange in the working frog heart; effects of overwork, external concentrations of potassium and ouabain.
Potassium and sodium exchange was studied in vitro in the working frog heart with the use of the radioactive isotopes K42 and Na24. Measurement of loss or gain of radioactivity, and hence the outfl...
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