EFFECTS OF POMEGRANATE JUICE ON HUMAN CYTOCHROME P450 3A (CYP3A) AND CARBAMAZEPINE PHARMACOKINETICS IN RATS

@article{Hidaka2005EFFECTSOP,
  title={EFFECTS OF POMEGRANATE JUICE ON HUMAN CYTOCHROME P450 3A (CYP3A) AND CARBAMAZEPINE PHARMACOKINETICS IN RATS},
  author={Muneaki Hidaka and Manabu Okumura and Ken-Ichi Fujita and Tetsuya Ogikubo and Keishi Yamasaki and Tomomi Iwakiri and Nao Setoguchi and Kazuhiko Arimori},
  journal={Drug Metabolism and Disposition},
  year={2005},
  volume={33},
  pages={644 - 648}
}
In this study, we investigated whether components of pomegranate could inhibit CYP3A-mediated drug metabolism. The ability of pomegranate to inhibit the carbamazepine 10,11-epoxidase activity of CYP3A was examined using human liver microsomes, and pomegranate juice was shown to be a potent inhibitor of human CYP3A. Addition of 25 μl (5.0% v/v) of pomegranate juice resulted in almost complete inhibition of the carbamazepine 10,11-epoxidase activity of human CYP3A (1.8%). The inhibition potency… Expand
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Effects of Pomegranate Juice on Human Cytochrome P450 2C9 and Tolbutamide Pharmacokinetics in Rats
TLDR
It is discovered that pomegranate juice inhibited human CYP2C9 activity and furthermore increased tolbutamide bioavailability in rats. Expand
INFLUENCE OF POMEGRANATE JUICE ON THE CYP3A4-MEDIATED METABOLISM AND P-GLYCOPROTEIN MEDIATED TRANSPORT OF SAQUINAVIR IN VIVO AND EX VIVO MODELS
Cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp) play an important role in the first pass metabolism thereby limits the oral bioavailability of many clinically important and frequently… Expand
Pomegranate Juice Does Not Impair Clearance of Oral or Intravenous Midazolam, a Probe for Cytochrome P450‐3A Activity: Comparison With Grapefruit Juice
TLDR
Pomegranate juice does not alter clearance of intravenous or oral midazolam, whereas GFJ impairs clearance and elevates plasma levels of oralMidazolAM, suggesting mechanism‐based inhibition by GFJ but not PJ. Expand
Pomegranate juice does not affect the disposition of simvastatin in healthy subjects
TLDR
It is suggested that pomegranate juice affects little on the disposition of simvastatin in humans, and does not seem to have a clinically relevant inhibitory potential on CYP3A4 activity. Expand
Effect of 2 weeks' consumption of pomegranate juice on the pharmacokinetics of a single dose of midazolam: an open-label, randomized, single-center, 2-period crossover study in healthy Japanese volunteers.
TLDR
In this small Japanese adult volunteer population receiving single subtherapeutic doses of midazolam, 2 weeks' consumption of pomegranate juice did not significantly alter the pharmacokinetic profile of midAZolam compared with that of the control. Expand
Effects of Paeonia emodi on hepatic cytochrome P450 (CYP3A2 and CYP2C11) expression and pharmacokinetics of carbamazepine in rats.
TLDR
A reduction in the metabolic capacity responsible for CBZ clearance appears to be the mechanism behind this herb-drug interaction, and the concomitant administration of PE and CBZ should be viewed cautiously. Expand
TRANSIENT INHIBITION OF CYP3A IN RATS BY STAR FRUIT JUICE
TLDR
The results suggest that star fruit juice impairs the function of enteric CYP3A, but not of hepatic CYP2A, and that the effect of star fruit Juice is mainly reversible and transient. Expand
Effects of poloxamer 407-induced hyperlipidemia on the pharmacokinetics of carbamazepine and its 10,11-epoxide metabolite in rats: Impact of decreased expression of both CYP3A1/2 and microsomal epoxide hydrolase
TLDR
Findings have potential therapeutic implications assuming that the HL rat model qualitatively reflects similar changes in patients with hyperlipidemia, and caution is required regarding pharmacotherapy in thehyperlipidemic state in cases where drugs that are metabolized principally by CYP3A1/2 or mEH and have a narrow therapeutic range are in use. Expand
Effect of pomegranate juice pre-treatment on the transport of carbamazepine across rat intestine
TLDR
It seems that pomegranate juice might have induced CYP3A4 enzymes and hence drug is extensively metabolized. Expand
Effects of Grapefruit and Pomegranate Juices on the Pharmacokinetic Properties of Dapoxetine and Midazolam in Healthy Subjects
TLDR
The results suggest that GFJ increases the extent of absorption and reduces clearance of dapoxetine possibly by inhibition of both intestinal and hepatic CYP3A4, whereas PJ has little effect on dap oxetine pharmacokinetics. Expand
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TLDR
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