EFFECTS OF POMEGRANATE JUICE ON HUMAN CYTOCHROME P450 3A (CYP3A) AND CARBAMAZEPINE PHARMACOKINETICS IN RATS

@article{Hidaka2005EFFECTSOP,
  title={EFFECTS OF POMEGRANATE JUICE ON HUMAN CYTOCHROME P450 3A (CYP3A) AND CARBAMAZEPINE PHARMACOKINETICS IN RATS},
  author={Muneaki Hidaka and Manabu Okumura and Ken-Ichi Fujita and Tetsuya Ogikubo and Keishi Yamasaki and Tomomi Iwakiri and Nao Setoguchi and Kazuhiko Arimori},
  journal={Drug Metabolism and Disposition},
  year={2005},
  volume={33},
  pages={644 - 648}
}
In this study, we investigated whether components of pomegranate could inhibit CYP3A-mediated drug metabolism. The ability of pomegranate to inhibit the carbamazepine 10,11-epoxidase activity of CYP3A was examined using human liver microsomes, and pomegranate juice was shown to be a potent inhibitor of human CYP3A. Addition of 25 μl (5.0% v/v) of pomegranate juice resulted in almost complete inhibition of the carbamazepine 10,11-epoxidase activity of human CYP3A (1.8%). The inhibition potency… Expand
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TLDR
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TLDR
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TLDR
It seems that pomegranate juice might have induced CYP3A4 enzymes and hence drug is extensively metabolized. Expand
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The results suggest that GFJ increases the extent of absorption and reduces clearance of dapoxetine possibly by inhibition of both intestinal and hepatic CYP3A4, whereas PJ has little effect on dap oxetine pharmacokinetics. Expand
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