EFFECTS OF POMEGRANATE JUICE ON HUMAN CYTOCHROME P450 3A (CYP3A) AND CARBAMAZEPINE PHARMACOKINETICS IN RATS

@article{Hidaka2005EFFECTSOP,
  title={EFFECTS OF POMEGRANATE JUICE ON HUMAN CYTOCHROME P450 3A (CYP3A) AND CARBAMAZEPINE PHARMACOKINETICS IN RATS},
  author={Muneaki Hidaka and Manabu Okumura and Ken-Ichi Fujita and Tetsuya Ogikubo and Keishi Yamasaki and Tomomi Iwakiri and Nao Setoguchi and Kazuhiko Arimori},
  journal={Drug Metabolism and Disposition},
  year={2005},
  volume={33},
  pages={644 - 648}
}
In this study, we investigated whether components of pomegranate could inhibit CYP3A-mediated drug metabolism. The ability of pomegranate to inhibit the carbamazepine 10,11-epoxidase activity of CYP3A was examined using human liver microsomes, and pomegranate juice was shown to be a potent inhibitor of human CYP3A. Addition of 25 μl (5.0% v/v) of pomegranate juice resulted in almost complete inhibition of the carbamazepine 10,11-epoxidase activity of human CYP3A (1.8%). The inhibition potency… 

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