EFFECTS OF ERVATAMINE CHLORHYDRATE ON CARDIAC MEMBRANE CURRENTS IN FROG ATRIAL FIBRES

@article{Sauviat1980EFFECTSOE,
  title={EFFECTS OF ERVATAMINE CHLORHYDRATE ON CARDIAC MEMBRANE CURRENTS IN FROG ATRIAL FIBRES},
  author={M. Sauviat},
  journal={British Journal of Pharmacology},
  year={1980},
  volume={71}
}
  • M. Sauviat
  • Published 1980
  • Chemistry, Medicine
  • British Journal of Pharmacology
1 The effects of a new alkaloid, ervatamine, on transmembrane currents of frog atrial fibres were studied by the double sucrose gap voltage clamp technique. 2 Ervatamine (2.8 × 10−4 m) blocked the action potential without altering the resting membrane potential. 3 The alkaloid depressed the peak INa. The dissociation constant for the blocking effect of ervatamine on gNa fast was 2.35 × 10−5 m with a one to one relationship between the drug molecule and the Na channel. Ervatamine did not alter… Expand
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