EFFECTS OF CALMODULIN ANTAGONISTS ON TENSION AND CELLULAR CALCIUM CONTENT IN DEPOLARIZED VASCULAR AND INTESTINAL SMOOTH MUSCLES

@article{Karaki1982EFFECTSOC,
  title={EFFECTS OF CALMODULIN ANTAGONISTS ON TENSION AND CELLULAR CALCIUM CONTENT IN DEPOLARIZED VASCULAR AND INTESTINAL SMOOTH MUSCLES},
  author={H. Karaki and K. Murakami and H. Nakagawa and Hiroshi Ozaki and Norimoto Urakawa},
  journal={British Journal of Pharmacology},
  year={1982},
  volume={77}
}
1 Several putative calmodulin antagonists have been examined for their inhibitory action on muscle tension and cellular Ca content in the K‐depolarized vascular and intestinal smooth muscles. 2 The 65.4 mm K‐induced sustained contraction in the media‐intimal layer of rabbit aorta and the 45.4 mm K‐induced sustained contraction in guinea‐pig taenia coli were inhibited by the calmodulin antagonists, prenylamine, chlorpromazine, N2‐dansyl‐l‐argiiiine‐4‐t‐butylpiperadine amide (No. 233), and N‐(6… 
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References

SHOWING 1-10 OF 38 REFERENCES
Influence of chlorpromazine on calcium movements and contractile responses of guinea-pig ileum longitudinal smooth muscle to agonists.
: The effects of chlorpromazine (CPZ) on the uptake and release of calcium by microsomes prepared from longitudinal smooth muscle of guinea-pig ileum (GPI) in vitro and on contractions of
Influence of chlorpromazine on calcium movements and contractile responses of guinea-pig ileum longitudinal smooth muscle to agonists.
The effects of chlorpromazine (CPZ) on the uptake and release of calcium by microsomes prepared from longitudinal smooth muscle of guinea-pig ileum (GPI) in vitro and on contractions of longitudinal
Effects of various calmodulin antagonists on contraction of rabbit aortic strips.
TLDR
Each Calmodulin antagonist tested has a different spectrum of action and of these only W-7 has a specific interaction with calmodulin.
Inhibitors of mitochondrial Ca++ uptake dissociate potassium-induced tension responses from increased 45Ca retention in rabbit aortic smooth muscle.
TLDR
The correlation between K+-induced uptake of Ca++ and an increased retention of La+++-resistant low affinity Ca++ after exposure to K+ are sequential events that can be associated by inhibitors of mitochondrial Ca++ uptake.
The mode of contractile action of palytoxin on vascular smooth muscle.
A novel vascular relaxing agent, N-(6--aminohexyl)-5-chloro-1-naphthalensulfonamide which affects vascular smooth muscle actomyosin.
TLDR
The facts suggest that W-7 produces relaxation of isolated vascular strips by inhibiting actin and myosin interaction, and does not act through beta adrenergic or cholinergic receptors.
Calcium-regulated modulator protein interacting agents inhibit smooth muscle calcium-stimulated protein kinase and ATPase.
TLDR
The results suggest that agents that interact with modulator protein produce relaxation of smooth muscle by inhibition of modulatorprotein-dependent myosin light chain phosphorylation thus suppressing the actin-myosin interaction and concomitant myOSin ATPase activation.
Antagonizing action of chlorpromazine, dibenamine, and phenoxybenzamine on potassium-induced contraction.
TLDR
It was found that the three agents blocking the potassium-induced contraction inhibited calcium-45 uptake during these contractions; however, they did not inhibit the calcium- 45 uptake of unstimulated muscle.
...
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