EFFECTS OF CALMODULIN ANTAGONISTS ON TENSION AND CELLULAR CALCIUM CONTENT IN DEPOLARIZED VASCULAR AND INTESTINAL SMOOTH MUSCLES

@article{Karaki1982EFFECTSOC,
  title={EFFECTS OF CALMODULIN ANTAGONISTS ON TENSION AND CELLULAR CALCIUM CONTENT IN DEPOLARIZED VASCULAR AND INTESTINAL SMOOTH MUSCLES},
  author={H. Karaki and K. Murakami and H. Nakagawa and H. Ozaki and N. Urakawa},
  journal={British Journal of Pharmacology},
  year={1982},
  volume={77}
}
1 Several putative calmodulin antagonists have been examined for their inhibitory action on muscle tension and cellular Ca content in the K‐depolarized vascular and intestinal smooth muscles. 2 The 65.4 mm K‐induced sustained contraction in the media‐intimal layer of rabbit aorta and the 45.4 mm K‐induced sustained contraction in guinea‐pig taenia coli were inhibited by the calmodulin antagonists, prenylamine, chlorpromazine, N2‐dansyl‐l‐argiiiine‐4‐t‐butylpiperadine amide (No. 233), and N‐(6… Expand
Influence of Calcium Entry Blockers and Calmodulin Inhibitors on 5‐Hydroxytryptamine‐, Potassium‐ and Calcium‐induced Contractions in Human Umbilical Artery In‐vitro
TLDR
Findings indicate that the mechanisms by which these drugs exert their inhibitory effects on human umbilical artery are markedly different from those reported in other vascular beds. Expand
Functional interactions of calcium‐antagonists in K+‐depolarized smooth muscle
  • M. Spedding
  • Chemistry, Medicine
  • British journal of pharmacology
  • 1983
TLDR
The relaxant effects of nimodipine were similar in the presence of nifedipine, diltiazem and cinnarizine, but were slightly attenuated in the absence of verapamil and W‐7, a calmodulin antagonist. Expand
The inhibitory effects of N2‐dansyl‐l‐arginine‐4‐t‐butylpiperidine amide (TI 233) on contraction of vascular and intestinal smooth muscle
TLDR
It was concluded that TI 233 inhibits the vascular and intestinal smooth muscle contraction by a Ca antagonistic action and also by inhibition of aerobic metabolism. Expand
Interactions between a “calcium channel agonist”, Bay K 8644, and calcium antagonists differentiate calcium antagonist subgroups in K+-depolarized smooth muscle
TLDR
Bay K 8644 increased the sensitivity to Ca2+ of K+-depolarized taenia preparations from the guinea-pig caecum and defined subgroups of calcium antagonists which are the same as those previously reported from functional studies. Expand
Effects of calcium antagonists on release of [3H]noradrenaline in rabbit aorta.
TLDR
It is suggested that the evoked release of noradrenaline in rabbit aorta is relatively insensitive to organic Ca antagonists and calmodulin antagonists, and that high concentrations of these inhibitors themselves release nor adrenaline by a mechanism independent of external Ca. Expand
Frequency-dependent inhibition of the intracellular calcium transients by calmodulin antagonists in the aequorin-injected rabbit papillary muscle.
  • M. Endoh
  • Chemistry, Medicine
  • Advances in experimental medicine and biology
  • 1989
TLDR
The effects of calmodulin antagonists, W-7 and trifluoperazine (TFP), on the intracellular calcium transients and isometric contractions were assessed simultaneously in the isolated rabbit papillary muscle, superficial cells of which had been microinjected with the Ca2+ sensitive bioluminescent protein aequorin. Expand
Changing surface charge with salicylate differentiates between subgroups of calcium‐antagonists
  • M. Spedding
  • Chemistry, Medicine
  • British journal of pharmacology
  • 1984
TLDR
It is argued that salicylate increases the effectiveness of cinnarizine by increasing accumulation of this drug in the cell membrane or at intracellular sites whereas the reduced effectiveness of verapamil and diltiazem is secondary to a change in the state of the Ca2+ channel. Expand
In vitro effects of calcium entry blockers, chlorpromazine and fenoterol upon human pregnant myometrium contractility
TLDR
Calcium influx and calmodulin are involved in spontaneous contractions of pregnant human myometrium in vitro, and it is suggested that calcium channels activated by these conditions could be different. Expand
Contraction of smooth muscle in Ca-free solution.
TLDR
The tonic contractions which are extremely resistant to removal of the external Ca were investigated in the rat vas deferens and myometrium and may suggest that the receptor-mediated contractions resistant to Ca-removal are caused by some process without a contribution of the Ca-calmodulin system. Expand
Use of tension measurements to delineate the mode of action of vasodilators.
Direct experimental procedures to delineate the modes of inhibition of drugs on vascular smooth muscle contractility are described. In isolated rabbit aortic strips, high concentrations of KCl andExpand
...
1
2
3
4
...

References

SHOWING 1-10 OF 38 REFERENCES
Influence of chlorpromazine on calcium movements and contractile responses of guinea-pig ileum longitudinal smooth muscle to agonists.
: The effects of chlorpromazine (CPZ) on the uptake and release of calcium by microsomes prepared from longitudinal smooth muscle of guinea-pig ileum (GPI) in vitro and on contractions ofExpand
Influence of chlorpromazine on calcium movements and contractile responses of guinea-pig ileum longitudinal smooth muscle to agonists.
The effects of chlorpromazine (CPZ) on the uptake and release of calcium by microsomes prepared from longitudinal smooth muscle of guinea-pig ileum (GPI) in vitro and on contractions of longitudinalExpand
Effects of various calmodulin antagonists on contraction of rabbit aortic strips.
TLDR
Each Calmodulin antagonist tested has a different spectrum of action and of these only W-7 has a specific interaction with calmodulin. Expand
Inhibitors of mitochondrial Ca++ uptake dissociate potassium-induced tension responses from increased 45Ca retention in rabbit aortic smooth muscle.
TLDR
The correlation between K+-induced uptake of Ca++ and an increased retention of La+++-resistant low affinity Ca++ after exposure to K+ are sequential events that can be associated by inhibitors of mitochondrial Ca++ uptake. Expand
The mode of contractile action of palytoxin on vascular smooth muscle.
TLDR
It is suggested that PTX increased Ca2+ influx into the smooth muscle cell to cause a contraction, which may be analogous to the action of high K+. Expand
Possible role of endogenous catecholamines in the contractions induced in rabbit aorta by ouabain, sodium depletion and potassium depletion.
TLDR
The data suggest that Na+ depletion, K+ depletion and ouabain release endogenous catecholamines which affect the contraction of the vascular smooth muscle of rabbit aorta. Expand
A novel vascular relaxing agent, N-(6--aminohexyl)-5-chloro-1-naphthalensulfonamide which affects vascular smooth muscle actomyosin.
TLDR
The facts suggest that W-7 produces relaxation of isolated vascular strips by inhibiting actin and myosin interaction, and does not act through beta adrenergic or cholinergic receptors. Expand
Calcium-regulated modulator protein interacting agents inhibit smooth muscle calcium-stimulated protein kinase and ATPase.
TLDR
The results suggest that agents that interact with modulator protein produce relaxation of smooth muscle by inhibition of modulatorprotein-dependent myosin light chain phosphorylation thus suppressing the actin-myosin interaction and concomitant myOSin ATPase activation. Expand
Antagonizing action of chlorpromazine, dibenamine, and phenoxybenzamine on potassium-induced contraction.
TLDR
It was found that the three agents blocking the potassium-induced contraction inhibited calcium-45 uptake during these contractions; however, they did not inhibit the calcium- 45 uptake of unstimulated muscle. Expand
Calmodulin stimulation of calcium uptake and (Ca2+-Mg2+)-ATPase activities in microsomes from canine tracheal smooth muscle.
TLDR
Results indicate that calmodulin may play a role in the control of the cytosolic [Ca2+]free in canine tracheal smooth muscle. Expand
...
1
2
3
4
...