EFFECTS OF ASCORBIC ACID ON MICROSOMAL DRUG METABOLISM *

@article{Zannoni1975EFFECTSOA,
  title={EFFECTS OF ASCORBIC ACID ON MICROSOMAL DRUG METABOLISM *},
  author={V. Zannoni and P. Sato},
  journal={Annals of the New York Academy of Sciences},
  year={1975},
  volume={258}
}
  • V. Zannoni, P. Sato
  • Published 1975
  • Chemistry, Medicine
  • Annals of the New York Academy of Sciences
Studies from a number of laboratories have shown that vitamin C deficiency in guinea pigs results in decreased metabolism of a variety of pharmacological agents.'-'" In 1941, Richards et al.' found a prolonged sleeping time in scorbutic guinea pigs given pentobarbital compared with that of normal animals, and the administration of ascorbic acid reversed the effect. Axelrod et a1.j in 1954 reported up to a threefold increase in plasma half-life of such agents as acetanilid, aniline, or… Expand
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