EFFECTS OF AGE ON DOPAMINE AND SEROTONIN RECEPTORS MEASURED BY POSITRON TOMOGRAPHY IN THE LIVING HUMAN BRAIN

@article{Wong1984EFFECTSOA,
  title={EFFECTS OF AGE ON DOPAMINE AND SEROTONIN RECEPTORS MEASURED BY POSITRON TOMOGRAPHY IN THE LIVING HUMAN BRAIN},
  author={Dean F. Wong and Henry N. Jr. Wagner and Robert F. Dannals and Jonathan M. Links and James J. Frost and Hayden T. Ravert and A. A. Wilson and Arthur E. Rosenbaum and Albert Gjedde and Kenneth H. Douglass and John D. Petronis and Marshal F. Folstein and Juey Kong Toung and H. Donald Burns and Michael J. Kuhar},
  journal={Journal of Computer Assisted Tomography},
  year={1984},
  volume={9},
  pages={642}
}
  • D. Wong, H. Wagner, M. Kuhar
  • Published 21 December 1984
  • Biology, Medicine, Psychology
  • Journal of Computer Assisted Tomography
D2 dopamine and S2 serotonin receptors were imaged and measured in healthy human subjects by positron emission tomography after intravenous injection of 11C-labeled 3-N-methylspiperone. Levels of receptor in the caudate nucleus, putamen, and frontal cerebral cortex declined over the age span studied (19 to 73 years). The decline in D2 receptor in males was different from that in females. 
Effect of age on D2 dopamine receptors in normal human brain measured by positron emission tomography and 11C-raclopride.
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The results suggest that D2 dopamine receptor binding sites (mainly postsynaptically located) decrease as a consequence of normal aging in parallel with the decline of the presynaptic nigrostriatal dopaminergic neuronal system.
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TLDR
The results suggest that dopamine D2 receptor binding sites (mainly post‐synaptically located) decrease as a consequence of normal aging in parallel with the decline of the pre‐synaptic nigrostriatal dopa‐minergic system.
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TLDR
The results document an age‐related decline in dopamine transporters in healthy individuals.
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TLDR
Studies of [11C]raclopride binding indicate that clinically effective doses of chemically distinct neuroleptic drugs result in 85 to 90 percent occupancy of D2 dopamine receptors in the putamen of schizophrenic patients.
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Summary— Probing the regional distribution and affinity of receptors in the brain, in vivo, in human and non human primates has become possible with the use of selective ligands labelled with
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TLDR
Amphetamine decreased glucose metabolism in all regions studied (frontal, temporal, and striatal) in normal and schizophrenic subjects and was correlated with plasma level of the drug.
Positron emission tomographic study of D2 dopamine receptor binding and CSF biogenic amine metabolites in Rett syndrome.
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The patient was found to have dopamine D2 receptor binding activity in the low normal range and the caudate/cerebellar activity ratio was below the mean regression line that relates the CA/CB ratio as a function of age.
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