EFFECT OF TWO DIFFERENT DILUENTS ON RELEASE PROFILE OF ACECLOFENAC FROM SUSTAINED RELEASE MATRIX TABLETS USING GUM DAMAR AS RELEASE RETARDANT

@inproceedings{Dhat2011EFFECTOT,
  title={EFFECT OF TWO DIFFERENT DILUENTS ON RELEASE PROFILE OF ACECLOFENAC FROM SUSTAINED RELEASE MATRIX TABLETS USING GUM DAMAR AS RELEASE RETARDANT},
  author={Shalaka Dhat and Sanjivani Aphale and Uddhav S. Bagul and N. Shah},
  year={2011}
}
In the present work the effect of two different diluents namely dicalcium phosphate (DCP) and maize starch (MS) on the release of aceclofenac from sustained release matrix tablets has been studied. Gum damar (GD), a hydrophobic polymer with significant binding property was used as a release retarding agent. In the present study aceclofenac was used as a model drug for developing sustained release matrix tablets owing to its short biological half life (4 hours) and dosing frequency more than one… CONTINUE READING