EFFECT OF THE ANGIOGENESIS INHIBITOR CILENGITIDE (EMD 121974) ON GLIOBLASTOMA GROWTH IN NUDE MICE

@article{Yamada2006EFFECTOT,
  title={EFFECT OF THE ANGIOGENESIS INHIBITOR CILENGITIDE (EMD 121974) ON GLIOBLASTOMA GROWTH IN NUDE MICE},
  author={Shinya Yamada and Xingyao Bu and Vazgen Khankaldyyan and Ignacio Gonzales-Gomez and J. Gordon McComb and Walter E. Laug},
  journal={Neurosurgery},
  year={2006},
  volume={59},
  pages={1304–1312}
}
OBJECTIVETo determine the effect of the angiogenesis inhibitor Cilengitide (EMD 121974) on glioblastoma growth and associated angiogenesis in the brains of nude mice. METHODSHuman glioblastoma cells (105 U87MG cells) in 1 μl of medium were stereotactically injected during a 20-minute period into the caudate/putamen of nude mice. The mice were intraperitoneally treated daily with Cilengitide or solvent (control) beginning 5 days after tumor injection. The mice were sacrificed from 1 hour to 63… Expand
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