EFFECT OF RIBAVIRIN ON TYPE 2 HERPESVIRUS HOMINIS (HVH/2) IN VITRO AND IN VIVO

@article{Allen1977EFFECTOR,
  title={EFFECT OF RIBAVIRIN ON TYPE 2 HERPESVIRUS HOMINIS (HVH/2) IN VITRO AND IN VIVO},
  author={Lois B. Allen and S M Wolf and Caleb J. Hintz and John H. Huffman and Robert William Sidwell},
  journal={Annals of the New York Academy of Sciences},
  year={1977},
  volume={284}
}
Ribavirin was found to inhibit five strains of HVH/2 tested in KB cells with the M1C range being 10-100 microgram/ml. In a mouse tail animal model, it effectively reduced HVH/2-induced lesions particularly at the peak lesion periods. Ribavirin was remarkably effective when intravaginal treatment was initiated late in the infection, which suggests that it may have potential for treatment of human cutaneous infections. 
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11 Citations

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References

SHOWING 1-10 OF 17 REFERENCES
Resistance to herpes simplex type 2 virus induced by an immunopotentiator (pyran) in immunosuppressed mice.
TLDR
The results suggest a possible role for immunopotentiator-activated macrophages in the increased resistance afforded mice by treatment with pyran in protecting both normal or TXB mice against lethal infection with the herpes virus.
Resistance of Female Mice to Vaginal Infection Induced by Herpesvirus hominis Type 2: Effects of Immunization with Mycobacterium bovis, Intravenous Injection of Specific Herpesvirus hominis Type 2 Antiserum, and a Combination of These Procedures
TLDR
Synergistic interaction of BCG immunization and treatment with SAS produced the greatest degree of protection in mice challenged intravaginally with HVH2, whereas a single 0.5-ml intravenous injection of SAS provided significant protection.
Effect of 1-β-d-Ribofuranosyl-1,2,4-Triazole-3-Carboxamide (Virazole, ICN 1229) on Herpes and Vaccinia Keratitis and Encephalitis in Laboratory Animals
Topical application of 1-β-d-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole) significantly inhibited the development of herpetic keratitis in the eyes of rabbits, as determined by both…
Genital herpesvirus hominis infection in mice. I. Development of an experimental model
Pregnant female mice, after intravaginal inoculation with Herpesvirus hominis (HVH) type 2, developed vaginitis on days 5 to 7 after virus challenge, followed by hunching and hind limb paralysis on…
In Vitro Effect of 1-β-d-Ribofuranosyl-1,2,4-Triazole-3-Carboxamide (Virazole, ICN 1229) on Deoxyribonucleic Acid and Ribonucleic Acid Viruses
TLDR
Parallel experiments indicated Virazole to have at least a comparable degree of activity, and it was also active against a wider variety of viruses than any of these known active materials.
Effect of herpesvirus type 2 and hormonal imbalance on the uterine cervix of the mouse.
  • N. Muñoz
  • Biology, Medicine
    Cancer research
  • 1973
TLDR
Results suggest that, at least in these three animals, HSV-2 may have a role in tumor induction and progesterone has been found to exert a protective effect against chemical carcinogens in the mouse cervix.
36 Experimental Genital Herpes Simplex infection in the Mouse
TLDR
Evidence has been obtained that the newborn mouse becomes infected with herpes simplex virus on passage through the infected birth canal of the mother mouse and differentiate herpes strains obtained from human genital lesions from strains recovered from nongenital sites.
Use of disposable micro tissue culture plates for antiviral and interferon induction studies.
TLDR
A reproducible test system requiring small amounts of test compound was developed for evaluating antiviral and interferon-inducing activity and known active compounds evaluated in this microplate system had activity similar to that seen in macro in vitro systems.
Genital herpes simplex infection. Virologic and cytologic studies.
Design, synthesis, and broad spectrum antiviral activity of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide and related nucleosides.
...
...