EFFECT OF NIFEDIPINE ON ANALGESIA INDUCED BY GABAa AND GABAB RECEPTOR AGONISTS IN RATS

@inproceedings{Harro2013EFFECTON,
  title={EFFECT OF NIFEDIPINE ON ANALGESIA INDUCED BY GABAa AND GABAB RECEPTOR AGONISTS IN RATS},
  author={J. Bouwmeester Harro and Amanda L. S. Lang and A. Pavithra and Т. and Leif Bertilsson},
  year={2013}
}
In the present study, we found that DHP calcium channel antagonist nifedipine exerted an antinociceptive activity following systemic adminis­ tration. In agreement with earlier observations, these data suggest that nifedipine might possess a certain analgesic properties. In order to test a possibility that GABA-sensitive mechanisms may be involved in the antinociceptive effect of nifedipine, series of experiments were carried out in which the effects of subanalgesic dose of nifedipine on… CONTINUE READING

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