EFFECT OF LIPID PEROXIDATION ON COVALENT BINDING OF ACTIVE METABOLITE OF ACETAMINOPHEN TO LIVER MICROSOMAL MACROMOLECULES IN SEVERAL ANIMAL SPECIES

@inproceedings{Aikawa1978EFFECTOL,
  title={EFFECT OF LIPID PEROXIDATION ON COVALENT BINDING OF ACTIVE METABOLITE OF ACETAMINOPHEN TO LIVER MICROSOMAL MACROMOLECULES IN SEVERAL ANIMAL SPECIES},
  author={Kazuo Aikawa and Tetsuo Satoh and Keiko Kobayashi and Haruo Kitagawa},
  year={1978}
}
There was good correlation of lipid peroxidation and covalent binding of acetaminophen (AAP) to liver microsomal protein in mice, guinea pigs and rabbits, but not in rats. By increasing concentrations of EDTA which is an inhibitor of lipid peroxidation, the degree of microsomal lipid peroxidation decreased in mice, guinea pigs, rabbits and rats, and the amount of covalent binding of AAP metabolite to liver microsomal protein increased in mice, guinea pigs and rabbits, but no consistent results… CONTINUE READING