EFFECT OF GRANULOCYTE COLONY STIMULATING FACTOR ON NEUTROPENIA INDUCED BY CYTOTOXIC CHEMOTHERAPY

@article{Morstyn1988EFFECTOG,
  title={EFFECT OF GRANULOCYTE COLONY STIMULATING FACTOR ON NEUTROPENIA INDUCED BY CYTOTOXIC CHEMOTHERAPY},
  author={G. Morstyn and J. Keech and W. Sheridan and L. Campbell and M. Green and D. Metcalf and R. Fox and L. Souza and N. Alton},
  journal={The Lancet},
  year={1988},
  volume={331},
  pages={667-672}
}
A phase I/II study of granulocyte colony stimulating factor (G-CSF) was undertaken in patients with advanced malignancy receiving melphalan to determine the granulocyte response, side-effects, and pharmacokinetics. Patients received doses of 1-60 micrograms/kg intravenously. There were 3 patients at each dose level. Before chemotherapy the immediate effect of G-CSF was a transient depression in circulating neutrophils followed by a dose-dependent rise. Neutrophil counts up to 80 X 10(9)/l were… Expand
Clinical trial of recombinant granulocyte colony-stimulating factor for chemotherapy-induced neutropenia patients with oral cancer.
Treatment of chemotherapy-induced neutropenia by subcutaneously administered granulocyte colony-stimulating factor with optimization of dose and duration of therapy.
  • G. Morstyn, L. Campbell, +7 authors K. Alton
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 1989
Treatment of cyclic neutropenia with granulocyte colony-stimulating factor.
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