EFFECT OF CEPHALOSPORINS ON y-AMINOBUTYRIC ACID RECEPTOR BINDING WITH OR WITHOUT NON-STEROIDAL ANTI-INFLAMMATORY DRUGS

@inproceedings{Seiji2006EFFECTOC,
  title={EFFECT OF CEPHALOSPORINS ON y-AMINOBUTYRIC ACID RECEPTOR BINDING WITH OR WITHOUT NON-STEROIDAL ANTI-INFLAMMATORY DRUGS},
  author={Seiji and Hori and Keiji and Kanemitsu and Jingoro and Shimada},
  year={2006}
}
Cephalosporins have been well known to have potent convulsant activity. Westudied the mechanism of the convulsions induced by cephalosporins. Cefazolin, cephaloridine, cefpirome and cefmetazole inhibited the receptor binding of y-aminobutyric acid (GABA), an inhibitory transmitter in the mammaliancentral nervous system. As fluoroquinolones also inhibited GABAreceptor binding and this inhibition was enhanced in the presence of non-steroidal anti-inflammatory drugs (NSAIDs), we studied the effect… CONTINUE READING
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