EFFECT OF 5- AND 6-PROPYLTHIOURACIL ON THE METABOLISM OF L-THYROXINE IN MAN.

@article{Hershman1964EFFECTO5,
  title={EFFECT OF 5- AND 6-PROPYLTHIOURACIL ON THE METABOLISM OF L-THYROXINE IN MAN.},
  author={Jerome M. Hershman},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1964},
  volume={24},
  pages={
          173-9
        }
}
  • J. Hershman
  • Published 1 February 1964
  • Chemistry, Medicine
  • The Journal of clinical endocrinology and metabolism
The effect of 5-propylthiouracil (5-PTU) and 6-propylthiouracil (6-PTU) on the metabolism of thyroxine was studied in 10 euthyroid patients. After a single dose of I131-labeled L-thyroxine given intravenously, radioactivity in the serum, urine and stool was measured daily. Potassium perchlorate was given throughout the study to block recycling of iodide by the thyroid. After an 8- to 9-day control period, either 5-PTU (400 mg daily) or 6-PTU (400–800 mg daily) was given for 8 days. 5-PTU… Expand
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