EFF-1-mediated regenerative axonal fusion requires components of the apoptotic pathway

@article{Neumann2015EFF1mediatedRA,
  title={EFF-1-mediated regenerative axonal fusion requires components of the apoptotic pathway},
  author={Brent Neumann and Sean Coakley and Rosina Giordano-Santini and Casey Linton and Eui Seung Lee and Akihisa Nakagawa and Ding Xue and Massimo Antonio Hilliard},
  journal={Nature},
  year={2015},
  volume={517},
  pages={219-222}
}
Functional regeneration after nervous system injury requires transected axons to reconnect with their original target tissue. Axonal fusion, a spontaneous regenerative mechanism identified in several species, provides an efficient means of achieving target reconnection as a regrowing axon is able to contact and fuse with its own separated axon fragment, thereby re-establishing the original axonal tract. Here we report a molecular characterization of this process in Caenorhabditis elegans… CONTINUE READING
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Extended Data Figure 10 | Proposed model for how the apoptotic recognition molecules and the fusogen EFF-1 mediate axonal fusion during regeneration of PLM

  • Extended Data Figure 10 | Proposed model for how…

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