EFA6, a sec7 domain-containing exchange factor for ARF6, coordinates membrane recycling and actin cytoskeleton organization.

@article{Franco1999EFA6AS,
  title={EFA6, a sec7 domain-containing exchange factor for ARF6, coordinates membrane recycling and actin cytoskeleton organization.},
  author={M D Franco and Peter J Peters and Joelle Boretto and Elly van Donselaar and Alexander Neri and Crislyn D'Souza-Schorey and Philippe Chavrier},
  journal={The EMBO journal},
  year={1999},
  volume={18 6},
  pages={1480-91}
}
We have identified a human cDNA encoding a novel protein, exchange factor for ARF6 (EFA6), which contains Sec7 and pleckstrin homology domains. EFA6 promotes efficient guanine nucleotide exchange on ARF6 and is distinct from the ARNO family of ARF1 exchange factors. The protein localizes to a dense matrix on the cytoplasmic face of plasma membrane invaginations, induced on its expression. We show that EFA6 regulates endosomal membrane recycling and promotes the redistribution of transferrin… CONTINUE READING
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