EF-hand protein Ca2+ buffers regulate Ca2+ influx and exocytosis in sensory hair cells.

@article{Pangri2015EFhandPC,
  title={EF-hand protein Ca2+ buffers regulate Ca2+ influx and exocytosis in sensory hair cells.},
  author={Tina Pangr{\vs}i{\vc} and Mantas Gabrielaitis and Susann Michanski and Beat Schwaller and Fred R. Wolf and Nicola Strenzke and Tobias Moser},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 9},
  pages={E1028-37}
}
EF-hand Ca(2+)-binding proteins are thought to shape the spatiotemporal properties of cellular Ca(2+) signaling and are prominently expressed in sensory hair cells in the ear. Here, we combined genetic disruption of parvalbumin-α, calbindin-D28k, and calretinin in mice with patch-clamp recording, in vivo physiology, and mathematical modeling to study their role in Ca(2+) signaling, exocytosis, and sound encoding at the synapses of inner hair cells (IHCs). IHCs lacking all three proteins showed… CONTINUE READING
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