EF-P is essential for rapid synthesis of proteins containing consecutive proline residues.

@article{Drfel2013EFPIE,
  title={EF-P is essential for rapid synthesis of proteins containing consecutive proline residues.},
  author={Lili Klara D{\"o}rfel and Ingo Wohlgemuth and Christina Kothe and Frank Peske and Henning Urlaub and Marina V. Rodnina},
  journal={Science},
  year={2013},
  volume={339 6115},
  pages={
          85-8
        }
}
Elongation factor P (EF-P) is a translation factor of unknown function that has been implicated in a great variety of cellular processes. Here, we show that EF-P prevents ribosome from stalling during synthesis of proteins containing consecutive prolines, such as PPG, PPP, or longer proline strings, in natural and engineered model proteins. EF-P promotes peptide-bond formation and stabilizes the peptidyl-transfer RNA in the catalytic center of the ribosome. EF-P is posttranslationally modified… CONTINUE READING

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