EETs alleviate ox-LDL-induced inflammation by inhibiting LOX-1 receptor expression in rat pulmonary arterial endothelial cells.

@article{Jiang2014EETsAO,
  title={EETs alleviate ox-LDL-induced inflammation by inhibiting LOX-1 receptor expression in rat pulmonary arterial endothelial cells.},
  author={Jun-xia Jiang and Shui-juan Zhang and Yanan Liu and Xi-xi Lin and Yan-hong Sun and Hui-juan Shen and Xiao-feng Yan and Qiang-min Xie},
  journal={European journal of pharmacology},
  year={2014},
  volume={727},
  pages={
          43-51
        }
}
Oxidized low-density lipoprotein (Ox-LDL) is associated with atherosclerotic events through the modulation of arachidonic acid (AA) metabolism and activation of inflammatory signaling. Cytochrome P450 (CYP) epoxygenase-derived epoxyeicosatrienoic acids (EETs) mitigate inflammation through nuclear factor-κB (NF-κB). In this study, we explored the effects and mechanisms of exogenous EETs on the ox-LDL-induced inflammation of pulmonary artery endothelial cells (PAECs), which were cultured from rat… CONTINUE READING
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