EDD, a Ubiquitin-protein Ligase of the N-end Rule Pathway, Associates with Spindle Assembly Checkpoint Components and Regulates the Mitotic Response to Nocodazole*

  title={EDD, a Ubiquitin-protein Ligase of the N-end Rule Pathway, Associates with Spindle Assembly Checkpoint Components and Regulates the Mitotic Response to Nocodazole*},
  author={Flavia Scialpi and David J Mellis and Mark Ditzel},
  journal={The Journal of Biological Chemistry},
  pages={12585 - 12594}
Background: Mitotic progression is regulated by the spindle assembly checkpoint (SAC) to prevent aneuploidy and chromosome damage. Results: EDD binds to various SAC components, governs the expression levels of key mitosis-associated proteins, and mediates the response to the mitotic spindle poison nocodazole. Conclusion: EDD contributes to the ability of the SAC to mediate checkpoint arrest. Significance: EDD may act to maintain genomic integrity. In this work, we identify physical and genetic… 

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