EDA signaling and skin appendage development.

@article{Cui2006EDASA,
  title={EDA signaling and skin appendage development.},
  author={Chang-Yi Cui and David Schlessinger},
  journal={Cell cycle},
  year={2006},
  volume={5 21},
  pages={
          2477-83
        }
}
The same morphogenetic signals are often involved in the development of different organs. For developing skin appendages, a model for tissue-specific regulation of signaling is provided by the EDA pathway, which accesses the otherwise ubiquitous NFkappaB transcription factors. EDA signaling is mediated by ectodysplasin, EDAR and EDARADD, which form a new TNF ligand-receptor-adaptor family that is restricted to skin appendages in vertebrates from fish to human. The critical function of the… CONTINUE READING
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Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling complex and initiates gene transcription in skin appendage formation

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2018
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