ED-71, a vitamin D analog, is a more potent inhibitor of bone resorption than alfacalcidol in an estrogen-deficient rat model of osteoporosis.

@article{Uchiyama2002ED71AV,
  title={ED-71, a vitamin D analog, is a more potent inhibitor of bone resorption than alfacalcidol in an estrogen-deficient rat model of osteoporosis.},
  author={Yasushi Uchiyama and Yoshihiro Higuchi and Satoshi Takeda and Toshimi Masaki and Ayako Shira-Ishi and Kaori Sato and Noboru Kubodera and Kyoji Ikeda and Etsuro Ogata},
  journal={Bone},
  year={2002},
  volume={30 4},
  pages={582-8}
}
Although active vitamin D is used in certain countries for the treatment of osteoporosis, the risk of causing hypercalcemia/hypercalciuria means that there is only a narrow therapeutic window, and this has precluded worldwide approval. The results of our previous animal studies have suggested that the therapeutic effect of active vitamin D on bone loss after estrogen deficiency can be dissociated at least partly from its effect of enhancing intestinal calcium absorption and suppressing… CONTINUE READING

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