ECVAM retrospective validation of in vitro micronucleus test (MNT)

@article{Corvi2008ECVAMRV,
  title={ECVAM retrospective validation of in vitro micronucleus test (MNT)},
  author={Raffaella Corvi and Silvio Albertini and Thomas Hartung and Sebastian Hoffmann and Daniela Maurici and Stefan Pfuhler and Jan van Benthem and Philippe Vanparys},
  journal={Mutagenesis},
  year={2008},
  volume={23},
  pages={271 - 283}
}
  • Raffaella Corvi, Silvio Albertini, +5 authors Philippe Vanparys
  • Published 2008
  • Medicine, Biology
  • Mutagenesis
  • In the past decade several studies comparing the in vitro chromosome aberration test (CAT) and the in vitro micronucleus test (MNT) were performed. A high correlation was observed in each of the studies (>85%); however, no formal validation for the micronucleus in vitro assay had been carried out. Therefore, a working group was established by the European Centre for the Validation of Alternative Methods (ECVAM) to perform a retrospective validation of the existing data, in order to evaluate the… CONTINUE READING

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