ECM regulates MT1-MMP localization with β1 or αvβ3 integrins at distinct cell compartments modulating its internalization and activity on human endothelial cells

@article{Glvez2002ECMRM,
  title={ECM regulates MT1-MMP localization with β1 or αvβ3 integrins at distinct cell compartments modulating its internalization and activity on human endothelial cells},
  author={Beatriz G G{\'a}lvez and Salom{\'o}n Mat{\'i}as-Rom{\'a}n and Mar{\'i}a Y{\'a}{\~n}ez-M{\'o} and Francisco S{\'a}nchez-Madrid and Alicia G. Arroyo},
  journal={The Journal of Cell Biology},
  year={2002},
  volume={159},
  pages={509 - 521}
}
Regulation of membrane-type 1 matrix metalloproteinase (MT1-MMP) by different extracellular matrices (ECMs) on human endothelial cells (ECs) has been investigated. First, MT1-MMP is found at the intercellular contacts of confluent ECs grown on beta1 integrin-dependent matrix such as type 1 collagen (COL I), fibronectin (FN), or fibrinogen (FG), but not on gelatin (GEL) or vitronectin (VN). The novel localization of MT1-MMP at cell-cell contacts is assessed by confocal videomicroscopy of MT1-MMP… CONTINUE READING