ECM is required for skeletal muscle differentiation independently of muscle regulatory factor expression.

@article{Osses2002ECMIR,
  title={ECM is required for skeletal muscle differentiation independently of muscle regulatory factor expression.},
  author={Nelson Osses and Enrique Brandan},
  journal={American journal of physiology. Cell physiology},
  year={2002},
  volume={282 2},
  pages={C383-94}
}
Transcription of specific skeletal muscle genes requires the expression of the muscle regulatory factor myogenin. To assess the role of the extracellular matrix (ECM) in skeletal muscle differentiation, the specific inhibitors of proteoglycan synthesis, sodium chlorate and beta-D-xyloside, were used. Treatment of cultured skeletal muscle cells with each inhibitor substantially abolished the expression of creatine kinase and alpha-dystroglycan. This inhibition was totally reversed by the… CONTINUE READING

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