EC145: a novel targeted agent for adenocarcinoma of the lung.

@article{Pribble2012EC145AN,
  title={EC145: a novel targeted agent for adenocarcinoma of the lung.},
  author={Pamela Pribble and Martin J. Edelman},
  journal={Expert opinion on investigational drugs},
  year={2012},
  volume={21 5},
  pages={755-61}
}
INTRODUCTION EC145 is a folate receptor (FR)-targeted vinca alkaloid conjugate currently under development as an anticancer agent. The FR is overexpressed on a number of major malignancies including adenocarcinoma of the lung and ovarian cancer. A companion diagnostic radiopharmaceutical, EC20, allows for non-invasive determination of the presence of functionally active FR. AREAS COVERED This review will discuss the rationale for the FR as a target for anticancer agents, the pharmacology of… CONTINUE READING
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