EBV persistence in memory B cells in vivo.

  title={EBV persistence in memory B cells in vivo.},
  author={Gregory J. Babcock and Lisa L. Decker and Matthias Volk and David Thorley-Lawson},
  volume={9 3},
Epstein-Barr virus establishes latency in vitro by activating human B cells to become proliferating blasts, but in vivo it is benign. In the peripheral blood, the virus resides latently in resting B cells that we now show are restricted to the sIgD memory subset. However, in tonsils the virus shows no such restriction. We propose that EBV indiscriminately infects B cells in mucosal lymphoid tissue and that these cells differentiate to become resting memory B cells that then enter the… CONTINUE READING
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