EBV noncoding RNA EBER2 interacts with host RNA-binding proteins to regulate viral gene expression.

@article{Lee2016EBVNR,
  title={EBV noncoding RNA EBER2 interacts with host RNA-binding proteins to regulate viral gene expression.},
  author={Nara Lee and Therese A. Yario and Jessica S Gao and Joan A Steitz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 12},
  pages={
          3221-6
        }
}
Epstein-Barr virus (EBV) produces a highly abundant noncoding RNA called EBV-encoded RNA 2 (EBER2) that interacts indirectly with the host transcription factor paired box protein 5 (PAX5) to regulate viral latent membrane protein 1/2 (LMP1/2) gene expression as well as EBV lytic replication. To identify intermediary proteins, we isolated EBER2-PAX5-containing complexes and analyzed the protein components by mass spectrometry. The top candidates include three host proteins splicing factor… CONTINUE READING

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