EBV-miR-BHRF1-2 targets PRDM1/Blimp1: potential role in EBV lymphomagenesis

  title={EBV-miR-BHRF1-2 targets PRDM1/Blimp1: potential role in EBV lymphomagenesis},
  author={Jianwei Ma and Kui Nie and David C Redmond and Yuejun Liu and Olivier Elemento and Daniel M. Knowles and Wayne Tam},
PRDM1/Blimp1, a master regulator of B-cell terminal differentiation, has been identified as a tumor suppressor gene in aggressive lymphomas, including diffuse large B-cell lymphoma (DLBCL). It has been shown in DLBCL and Hodgkin lymphoma that PRDM1 is downregulated by cellular microRNAs. In this study, we identify the Epstein–Barr virus (EBV) microRNA (miRNA), EBV-miR-BHRF1-2, as a viral miRNA regulator of PRDM1. EBV-miR-BHRF1-2 repressed luciferase reporter activity by specific interaction… CONTINUE READING
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