EBV infection of human B lymphocytes leads to down-regulation of Bim expression: relationship to resistance to apoptosis.

@article{Clybouw2005EBVIO,
  title={EBV infection of human B lymphocytes leads to down-regulation of Bim expression: relationship to resistance to apoptosis.},
  author={Cyril Clybouw and Bouchra Mchichi and Shahul Mouhamad and Marie Th{\'e}r{\`e}se Auffredou and Marie Françoise Bourgeade and Surendra Sharma and G{\'e}rald Leca and Aim{\'e} V{\'a}zquez},
  journal={Journal of immunology},
  year={2005},
  volume={175 5},
  pages={2968-73}
}
EBV infects a large proportion of the human population worldwide and is one of the major viruses with human B lymphocyte tropism. It can immortalize human B lymphocytes and controls their resistance to apoptosis. EBV infection is associated with several lymphomas, including Burkitt's lymphoma. In this report we show that EBV infection leads to the post-transcriptional down-regulation of expression of the proapoptotic protein Bim. This process involves the phosphorylation of BimEL by the… CONTINUE READING