EBV-induced gene 3 transcription is induced by TLR signaling in primary dendritic cells via NF-kappa B activation.

@article{Wirtz2005EBVinducedG3,
  title={EBV-induced gene 3 transcription is induced by TLR signaling in primary dendritic cells via NF-kappa B activation.},
  author={Stefan Wirtz and Christoph Becker and Massimo Claudio Fantini and Edward E. S. Nieuwenhuis and Ingrid Tubbe and Peter Robert Galle and H J Schild and Mark Birkenbach and Richard S Blumberg and Markus F Neurath},
  journal={Journal of immunology},
  year={2005},
  volume={174 5},
  pages={2814-24}
}
The EBV-induced gene 3 (EBI3) is expressed in dendritic cells (DCs) and part of the cytokine IL-27 that controls Th cell development. However, its regulated expression in DCs is poorly understood. In the present study we demonstrate that EBI3 is expressed in splenic CD8(-), CD8(+), and plasmacytoid DC subsets and is induced upon TLR signaling. Cloning and functional analysis of the EBI3 promoter using in vivo footprinting and mutagenesis showed that stimulation via TLR2, TLR4, and TLR9… CONTINUE READING

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