EBV and systemic lupus erythematosus: a new perspective.

  title={EBV and systemic lupus erythematosus: a new perspective.},
  author={Andrew J. Gross and Donna Hochberg and W. M. Rand and David Thorley-Lawson},
  journal={Journal of immunology},
  volume={174 11},
We have proposed that EBV uses mature B cell biology to access memory B cells as a site of persistent infection. A central feature of this model is that EBV adapts its gene expression profile to the state of the B cell it resides in and that the level of infection is stable over time. This led us to question whether changes in the behavior or regulation of mature B cells would alter the state of EBV persistence. To investigate this, we studied the impact of systemic lupus erythematosus (SLE), a… CONTINUE READING