EBV PCR in the diagnosis and monitoring of posttransplant lymphoproliferative disorder: results of a two-arm prospective trial.

@article{Tsai2008EBVPI,
  title={EBV PCR in the diagnosis and monitoring of posttransplant lymphoproliferative disorder: results of a two-arm prospective trial.},
  author={Donald E Tsai and Lorrie Douglas and Charalampos G Andreadis and Dan T. Vogl and Sharon Arnoldi and Robert M. Kotloff and Jakub Svoboda and Roy D. Bloom and Kim M. Olthoff and Susan C. Brozena and Stephen J. Schuster and Edward A. Stadtmauer and Erle S Robertson and Mariusz A Wasik and Vivek N. Ahya},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2008},
  volume={8 5},
  pages={
          1016-24
        }
}
While EBV PCR is used in the management of PTLD, the optimal primer set, relative importance of intracellular versus free plasma EBV, and the baseline profile in an organ transplant population remains unclear. We performed a prospective 2-arm trial utilizing an EBV PCR panel measuring LMP-1, EBER-1 and EBNA-1 in both free plasma as well as intracellular whole blood. Control Arm A consisted of 31 lung transplant patients and Arm B consisted of 35 transplant patients being evaluated for possible… CONTINUE READING
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