EBV Noncoding RNA Binds Nascent RNA to Drive Host PAX5 to Viral DNA

@article{Lee2015EBVNR,
  title={EBV Noncoding RNA Binds Nascent RNA to Drive Host PAX5 to Viral DNA},
  author={Nara Lee and Walter N. Moss and Therese A. Yario and Joan A Steitz},
  journal={Cell},
  year={2015},
  volume={160},
  pages={607-618}
}
EBER2 is an abundant nuclear noncoding RNA expressed by the Epstein-Barr virus (EBV). Probing its possible chromatin localization by CHART revealed EBER2's presence at the terminal repeats (TRs) of the latent EBV genome, overlapping previously identified binding sites for the B cell transcription factor PAX5. EBER2 interacts with PAX5 and is required for the localization of PAX5 to the TRs. EBER2 knockdown phenocopies PAX5 depletion in upregulating the expression of LMP2A/B and LMP1, genes… CONTINUE READING
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