EBV Latent Membrane Protein 1 Activates Akt, NFκB, and Stat3 in B Cell Lymphomas

@article{Shair2007EBVLM,
  title={EBV Latent Membrane Protein 1 Activates Akt, NFκB, and Stat3 in B Cell Lymphomas},
  author={Kathy Ho Yen Shair and Katherine M Bendt and Rachel Hood Edwards and Elisabeth C Bedford and Judith N. Nielsen and Nancy Raab-Traub},
  journal={PLoS Pathogens},
  year={2007},
  volume={3},
  pages={2511 - 2573}
}
Latent membrane protein 1 (LMP1) is the major oncoprotein of Epstein-Barr virus (EBV). In transgenic mice, LMP1 promotes increased lymphoma development by 12 mo of age. This study reveals that lymphoma develops in B-1a lymphocytes, a population that is associated with transformation in older mice. The lymphoma cells have deregulated cell cycle markers, and inhibitors of Akt, NFkappaB, and Stat3 block the enhanced viability of LMP1 transgenic lymphocytes and lymphoma cells in vitro. Lymphoma… CONTINUE READING

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