EBV LMP1, a viral mimic of CD40, activates dendritic cells and functions as a molecular adjuvant when incorporated into an HIV vaccine.

@article{Gupta2011EBVLA,
  title={EBV LMP1, a viral mimic of CD40, activates dendritic cells and functions as a molecular adjuvant when incorporated into an HIV vaccine.},
  author={Sachin Gupta and James M. Termini and Liguo Niu and Saravana K Kanagavelu and Helena Schmidtmayerova and Victoria Snarsky and Richard S. Kornbluth and Geoffrey W Stone},
  journal={Journal of leukocyte biology},
  year={2011},
  volume={90 2},
  pages={
          389-98
        }
}
HIV-1 does not significantly activate cellular immunity, which has made it difficult to use attenuated forms of HIV-1 as a vaccine. In contrast, EBV induces robust T cell responses in most infected individuals, perhaps as this virus contains LMP1, a viral mimic of CD40, which is a key activating molecule for DCs and macrophages. Consequently, studies were conducted using LMP1 and LMP1-CD40, a related construct formed by replacing the intracellular signaling domain of LMP1 with that of CD40… CONTINUE READING

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