EBV BMRF-2 facilitates cell-to-cell spread of virus within polarized oral epithelial cells.

@article{Xiao2009EBVBF,
  title={EBV BMRF-2 facilitates cell-to-cell spread of virus within polarized oral epithelial cells.},
  author={Jianqiao Xiao and Joel M Palefsky and Rossana Herrera and Jennifer W. Berline and Sharof M Tugizov},
  journal={Virology},
  year={2009},
  volume={388 2},
  pages={
          335-43
        }
}
We previously reported that the Epstein-Barr virus (EBV) BMRF-2 protein plays an important role in EBV infection of polarized oral epithelial cells by interacting with beta1 and alphav family integrins. Here we show that infection of polarized oral epithelial cells with B27-BMRF-2(low) recombinant virus, expressing a low level of BMRF-2, resulted in significantly smaller plaques compared with infection by parental B95-8 virus. BMRF-2 localized in the trans-Golgi network (TGN) and basolateral… CONTINUE READING

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